Generic Name: phytonadione (fye toe na DYE own)
Brand names: Mephyton, Aquamephyton, Konakion, Vitamin K1
What is phytonadione?
Phytonadione is a man-made form of vitamin K, which occurs naturally in the body.
Phytonadione is used to treat vitamin K deficiency and to treat certain bleeding or blood clotting problems.
Phytonadione may also be used for purposes not listed in this medication guide.
What is the most important information I should know about phytonadione?
Never take phytonadione in larger amounts, or for longer than recommended by your doctor.
While using phytonadione, you may need blood tests at your doctor's office. Visit your doctor regularly.
If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using phytonadione.
What should I discuss with my healthcare provider before taking phytonadione?
You should not use phytonadione if you are allergic to it.
To make sure you can safely take phytonadione, tell your doctor if you have liver disease.
FDA pregnancy category C. It is not known whether phytonadione will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether phytonadione passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take phytonadione?
Take exactly as prescribed by your doctor. Never take phytonadione in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
While using phytonadione, you may need blood tests at your doctor's office. Visit your doctor regularly.
Use phytonadione regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using phytonadione. Store in the original container at room temperature away from moisture, heat, and light. Keep the container tightly closed when not in use.
See also: Phytonadione dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking phytonadione?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Phytonadione side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
dizziness;
fast or irregular heartbeats; or
increased sweating.
Call your doctor at once if you have a serious side effect such as:
feeling like you might pass out;
blue colored lips; or
trouble breathing.
Less serious side effects may include:
flushing (warmth, redness, or tingly feeling);
changes in your sense of taste;
sweating; or
dizziness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Phytonadione Dosing Information
Usual Adult Dose for Hypoprothrombinemia -- Anticoagulant Induced:
Active Rapid
INR Bleed Reversal Therapy & Follow-Up Comment
reduce dosage when resume therapy.
give 0.5 to 1 mg IM, subcutaneously,
or IV. Check INR in 8 hours. May
repeat 0.5 mg in 24 hours if needed.
6-10 No No Omit 1 to 4 anticoagulant doses. May
consider phytonadione 0.5 to 2 mg orally,
IM, subcutaneously, or IV. Check INR
in 8 hours (12 to 48 hours if given orally).
May repeat 0.5 mg in 24 to 48 hours if
needed.
10-20 No No Phytonadione 3 to 5 mg orally, IM,
subcutaneously, or IV. Check INR in
8 hours (12 to 48 hours if given orally).
May repeat 0.5 mg in 24 hours if needed.
> 20 or Yes -- Phytonadione 10 mg IM, subcutaneously,
or IV. Check INR every 6 hours and
repeat dose every 12 hours as needed.
In acute situations, give fresh frozen
plasma or factor concentrates and
phytonadione 10 mg, to be repeated
as needed.
Usual Adult Dose for Hypoprothrombinemia -- Not Associated with Anticoagulant Therapy:
2.5 to 25 mg orally, IM, subcutaneously, or IV.
The dosage, frequency, and route of administration should be determined by the severity of the condition.
If there is no bleeding and INR For active bleeding: 10 to 25 mg IM, subcutaneously, or IV.
When given by injection, the effects may not be apparent for up to 8 hours. Therefore, a transfusion with fresh frozen plasma or factor concentrates is recommended in serious or life-threatening situations. The INR may be checked in 8 to 12 hours following parenteral therapy or 12 to 48 hours following oral therapy, and dosage repeated if necessary.
Usual Adult Dose for Hypoprothrombinemia -- Prophylaxis:
2.5 to 10 mg orally or 1 to 10 mg IM, depending on the patient's condition. Malabsorption syndromes: 10 mg IM monthly.
Surgical correction of biliary obstruction: 5 mg IM once a day for 3 days prior to surgery.
Prolonged antibiotics in at risk patients: 10 mg orally, IM, or subcutaneously prior to or concurrent with the first antibiotic dose.
Malnourished, debilitated, or TPN patients: 1 mg IM once a week.
Usual Pediatric Dose for Hypoprothrombinemia -- Anticoagulant Induced:
Infants and children:
No bleeding, rapid reversal needed, anticoagulation to continue: 0.5 to 2 mg, intravenously or subcutaneously.
No bleeding, rapid reversal needed, patient NOT continuing anticoagulation: 2 to 5 mg, intravenously or subcutaneously.
Significant bleeding, not life-threatening: 0.5 to 2 mg intravenously or subcutaneously.
Significant bleeding and life-threatening: 5 mg intravenously.
Adolescents: 2.5 to 10 mg/dose, subcutaneously or intravenously; may repeat in 6 to 8 hours if given by subcutaneous or intravenous route; may repeat 12 to 48 hours after oral route.
Usual Pediatric Dose for Vitamin K Deficiency:
Infants and children:
2.5 to 5 mg orally once every 24 hours. Alternatively, 1 to 2 mg IV, IM or subcutaneously may be administered.
Adolescents:
2.5 to 25 mg orally once every 24 hours. Alternatively, 10 mg IV, IM or subcutaneously may be administered.
What other drugs will affect phytonadione?
Tell your doctor about all other medicines you use, especially:
an antibiotic;
salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others.
a blood thinner such as anisindione (Miradon), heparin, or warfarin (Coumadin); or
This list is not complete and other drugs may interact with phytonadione. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More phytonadione resources
- Phytonadione Side Effects (in more detail)
- Phytonadione Dosage
- Phytonadione Use in Pregnancy & Breastfeeding
- Phytonadione Drug Interactions
- Phytonadione Support Group
- 0 Reviews for Phytonadione - Add your own review/rating
- Phytonadione Prescribing Information (FDA)
- Phytonadione Monograph (AHFS DI)
- Phytonadione MedFacts Consumer Leaflet (Wolters Kluwer)
- Mephyton Advanced Consumer (Micromedex) - Includes Dosage Information
- Mephyton Prescribing Information (FDA)
- Mephyton MedFacts Consumer Leaflet (Wolters Kluwer)
- Vitamin K1 Prescribing Information (FDA)
Compare phytonadione with other medications
- Hypoprothrombinemia, Anticoagulant Induced
- Hypoprothrombinemia, Not Associated with Anticoagulant Therapy
- Hypoprothrombinemia, Prophylaxis
- Vitamin K Deficiency
Where can I get more information?
- Your pharmacist can provide more information about phytonadione.
See also: phytonadione side effects (in more detail)
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